Personalised medicine bases on your genes
Advances in genetics and genomics have made available the technology for us to gain invaluable information about our inherited susceptibilities at a reasonable cost. IMI’s DNA tests allow us to modify your gene expression by recommending lifestyle and nutritional changes. Our tests are not specific for genetic diseases but are related to genes that modify for example, your livers detoxification rate or predisposition to inflammation issues.
Once our IMI practitioners have this DNA data they can adapt their recommended supplements or advice to more precisely treat you – “personalised medicine” is the concept.
The DNA health test is designed to help our IMI practitioners to personalise a gene-based health plan with specific diet and lifestyle strategies for disease prevention, longevity and an effective healing by supporting your sub-optimal metabolic pathways.
It is a simple saliva test, suitable for adults, children, and even infants. The test measures the variations in 46 gene locations (SNP’s) related to 7 biological processes:
- Lipid metabolism (cholesterol risks)
Your LDL / HDL levels have a direct impact on your cardiovascular risks. Genes such as LPL, CETP, APOC3 and APOE play the key roles in your cholesterol metabolism and triglycerides catabolism, while the PON1 greatly affects the oxidation level of cholesterol, which is a factor in cardiovascular disease. With this information we can develop a dietary and supplement program to minimize the predispositions naturally and in a very targeted way.
- B vitamins/methylation
Methylation is a biochemical process that has a significant impact on your cardiovascular, neurological, reproductive and detoxification systems. This important process is kick-started by a critical B vitamin known as 5-MTHF (also known as active folate or methylfolate). However, about 40% of us have a genetic mutation that leads to subpar production of 5-MTHF. Genes related to the methylation process includes MTHFR, MTR, COMT, MTRR, and CBS. These in turn govern detoxification, (e.g. removal of homocysteine), and the production of our brains neurotransmitters. This part of the test often gives deep insights to the predisposition to anxiety or depression and how you can address this in a way that can stabilize you lifelong, without the need for drugs.
- Oxidative stress
Your ability to handle oxidative stress is important to your long-term health and disease prevention. Genes such as eNOS, MnSOD/SOD2, CAT, GPX1 influence your anti-oxidant activities. These genes when fully activated protect your DNA and important tissues such as your brain from oxidation and rapid ageing.
- Bone health
VDRhas a profound influence on bone density, while COL1A1 affects bone collagen formation, bone mineralization and strength. If these are not so functional recommendations can be targeted that may prevent future osteoporosis risks.
A thorough analysis of phase 1 and phase 2 detoxification enzyme functions can reflect your ability to produce sufficient glutathione—a key cellular detoxifier. This ability is essential for elimination of mutagenic and carcinogenic compounds from the body. Genes looked at include CYP1A1, GSTM1, GSTP1, GSTT1, and NQO1.
Your ability to reduce inflammation is the key in your response to injury, infection, and allergies. Chronic inflammation can lead to long-term diseases and cancers. IL-1B, IL-6 and TNF-A are crucial genes that can govern inflammation, and if the individual has the dysfunctional SNP’s, then auto-immune disease and pain conditions are more common, because of a hyper immune, excessive inflammatory response/ Knowing this a long-term safe natural anti-inflammatory strategy can be developed.
- Insulin resistance
Several genes affect your cell insulin sensitivity and susceptibility to type 2 diabetes and obesity. PPARG involves in glucose regulation and lipid metabolism, and TCF7LS and SLC2A2 influence insulin secretion and resistance. If these are present dietary modifications and certain specific herbs can be employed to minimise this predisposition.
Your practitioner will provide a thorough explanation along with specific advice or treatment plan based on the lab results, which usually arrive in 3 to 4 weeks after a saliva sample is submitted. See a sample report here.
“It is a proactive approach to disease prevention,” explains senior naturopathic physician Dr Benita Perch. “Many of these genetic vulnerabilities can be overcome by the right nutritional and lifestyle support, and if detected early, many DNA damages can be repaired.”
“It is never too early or too late to find out about your genetic blueprint and make the positive step towards a life-long wellness plan.”
In addition to the DNA Health test, IMI also offers:
- DNA diet, which provide in-depth analysis for diet optimisation and obesity prevention
- DNA sport, which focuses on power, endurance, and injury avoidance and recovery
- DNA estrogen, which looks in depth to your ability to safely detoxify and remove estrogen form the body.